0000024758 00000 n
0000022203 00000 n
0000036299 00000 n
In rats and humans up to 90% of radiolabel
In studies in hens given single oral doses of 20-300 mg/kg bw, omethoate did not induce delayed neurotoxicity. 0000010396 00000 n
0000027685 00000 n
0000024324 00000 n
0000008986 00000 n
147 0 obj<>stream
There was no accumulation in fat tissue. ECM - Dimethoate & Omethoate in Water - MRID 46276301 (PDF) (11 pp, 246 K) DER - Dimethoate & Omethoate in Water - MRID 46276301 (PDF) (12 pp, 1 MB) Contact Us to ask a question, provide feedback, or report a problem. Structure, properties, spectra, suppliers and links for: Omethoate, 1113-02-6. 0000010302 00000 n
CCPR scheduled dimethoate, omethoate and formothion for periodic review in 1998 (ALINORM 97/24). It is an irritant to the skin and mucous membranes.. Its toxicity and hazard potential are still under review because of concerns about its safety. Citrus only: • Estimate the drip zone area of the trees and calculate the quantity of DIMETHOATE 400 EC required for each tree. 0000029015 00000 n
0000019435 00000 n
0000018843 00000 n
0000023908 00000 n
0000008290 00000 n
0000028908 00000 n
Dimethoate is a widely used organophosphate insecticide and acaricide. There may be a need to re-evaluate the toxicity of dimethoate after the periodic review of the residue and analytical aspects of dimethoate has been completed if it is determined that omethoate is a major residue. �L. Sandra Ristori 0000023852 00000 n
0000036211 00000 n
0000019125 00000 n
0000025823 00000 n
0000008892 00000 n
0000033952 00000 n
Like other organophosphates, dimethoate is an acetylcholinesterase inhibitor which disables cholinesterase, an enzyme essential for central nervous system function. 0000034884 00000 n
0000021378 00000 n
0000025389 00000 n
Dimethoate (O,O-dimethyl S-methylcarbamoylmethyl phosphorodithioate) is an organophosphorus insecticide and acaricide used in agriculture and the home garden to control insects and mites. 0000019640 00000 n
0000018415 00000 n
It is used to control insects and mites in horticulture and agriculture, as well as in the home garden. 0000018944 00000 n
On the basis of minimal reductions in acetylcholinesterase activity of 10-20%, the NOAEL in a 12-month study in dogs at doses of 0, 5, 20, or 125 ppm was 5 ppm, equal to 0.2 mg/kg bw per day; in rats the NOAEL in a life-span study at doses of 0, 1, 5, 25, or 100 ppm was 1 ppm, equal to 0.04 mg/kg bw per day. 0000025655 00000 n
0000034003 00000 n
Retour à la référence de la note de bas de page 15. 0000027368 00000 n
0000032171 00000 n
Notes de bas de page 16. 0000031779 00000 n
0000029907 00000 n
0000034629 00000 n
0000018592 00000 n
0000012387 00000 n
0000028749 00000 n
0000020796 00000 n
0000028166 00000 n
Since the use of dimethoate does not lead to residues of formothion in treated produce, the toxicity of formothion was not considered at the present Meeting. 0000035137 00000 n
Appendix K. Review of ECOTOX database for dimethoate and omethoate Attachments Attachment 1: Status and Life History of California Red-legged Frog Attachment 2: Baseline Status and Cumulative Effects for the California Red-legged Frog List of Figures Figure 1. 145 0 obj<>
endobj
0000022525 00000 n
0000018329 00000 n
In a further multigeneration study of reproductive toxicity in rats at doses of 0, 0.5, 3, or 18 ppm in the drinking-water, there was evidence of epididymal vacuolation and fewer pups per dam at the high dose; these pups had lower weight gains and were less viable. Dimethoate was not a skin sensitizer in guinea-pigs, but a 32.7% emulsifiable concentrate formulation induced sensitization in one of 10 guinea-pigs. Dimethoate is a systemic and contact organophosphorus insecticide registered for use in the U.S. in 1962 and used on several field grown agricultural crops (e.g., leaf greens, citrus, and melons), tree crops, and ornamentals. 0000032579 00000 n
145 347
0000019014 00000 n
0000033490 00000 n
0000035596 00000 n
0000018914 00000 n
0000023054 00000 n
0000026089 00000 n
appl. • On plants and pests that are difficult to wet, e.g. 0000034935 00000 n
x�b```b`������������X��,�H Buy Omethoate (CAS 1113-02-6), an insecticidal, acaricidal, and fungicidal combination of carboxamides and other pesticides, from Santa Cruz. 0000021064 00000 n
0000036044 00000 n
0000019475 00000 n
Adama Dimethoate 400 Insecticide PAGE 1 OF 11 Adama Dimethoate ® 400 Insecticide adama.com CONTENTS: 5 L, 10 L, 20 L, 110 L, 200 L ACTIVE CONSTITUENT: 400 g/L DIMETHOATE (an anti-cholinesterase compound) GROUP 1B INSECTICIDE POISON KEEP OUT OF REACH OF CHILDREN READ SAFETY DIRECTIONS BEFORE OPENING OR USING For the control of certain insects including aphids, … <<5b0e0d41524cef4d93badb86c912c61c>]>>
dimethoate indicated that up to 18% of the administered label was excreted in
0000022789 00000 n
0000020541 00000 n
0000029174 00000 n
It is non-persistent in soil, mobile but does not normally persist in aerobic aquatic systems. 0000030334 00000 n
Apart from the inhibition of cholinesterase activity, dimethoate had no effect on the composition of the blood or urine. The Meeting therefore recommended that residues of dimethoate and omethoate resulting from the use of dimethoate be expressed as dimethoate and be assessed in comparison with the ADI for dimethoate. Dimethoate is rapidly absorbed after any route of administration in mammals. Biochemical evidence that an S431F mutation in acetylcholinesterase-1 of Aphis gossypii mediates resistance to pirimicarb and omethoate (Pest Management Science, 2004); Sister-chromatid exchanges in human lymphocytes induced by dimethoate, omethoate, deltamethrin, benomyl and their mixture. IMS is usually observed in individuals who have ingested a massive dose of an OP insecticide either accidentally or in a suicide attempt. 0000020391 00000 n
%%EOF
0000023259 00000 n
0000019852 00000 n
0000023427 00000 n
0000032838 00000 n
0000007867 00000 n
0000021687 00000 n
0000036105 00000 n
0000028698 00000 n
0000027312 00000 n
trailer
0000026570 00000 n
0000035535 00000 n
0000034425 00000 n
In hens given a single dose of 55 mg/kg bw by subcutaneous injection or orally, dimethoate did not induce delayed neurotoxicity. 0000021866 00000 n
0000023110 00000 n
In a poorly reported study in rabbits, sperm numbers and quality were adversely affected at doses equivalent to one-tenth and one-hundredth of the LD50. 0000033835 00000 n
0000025716 00000 n
0000022895 00000 n
The NOAEL was 1 ppm (equivalent to 0.05 mg/kg bw per day). 0000034828 00000 n
0000009832 00000 n
This ADI would usually be used only when assessing the intake of dimethoate itself. 0000007236 00000 n
0000024441 00000 n
0000032258 00000 n
Levels that cause no toxic effect (dimethoate), 1 ppm, equal to 0.04 mg/kg bw per day (two-year study of toxicity and carcinogenicity), 15 ppm, equal to 1.2 mg/kg bw per day (reproductive performance in a study of reproductive toxicity), 1 ppm, equal to 0.08 mg/kg bw per day (parental toxicity in a study of reproductive toxicity), 6 mg/kg bw per day (maternal toxicity in a study of developmental toxicity), 10 mg/kg bw per day (maternal toxicity in a study of developmental toxicity), 5 ppm, equal to 0.2 mg/kg bw per day (52-week study of toxicity), 0.2 mg/kg bw per day (39-day study of cholinesterase inhibition), Estimate of acceptable daily intake for humans, 0-0.002 mg/kg bw (sum of dimethoate and omethoate expressed as dimethoate). It is rapidly metabolized in the liver. The total toxicologically significant residues, calculated in this way, were used for the estimation of dietary exposure. 0000023586 00000 n
0000035020 00000 n
0000029811 00000 n
0000022111 00000 n
The precoital time was increased and the number of non-pregnant females was greater than among controls. The results of long-term studies of toxicity and carcinogenicity in mice (at 0, 25, 100, or 200 ppm) and rats (at 0, 5, 25, or 100 ppm) reported in 1986 and studies reported in 1977 indicate that dimethoate is not carcinogenic to rodents. was found in the urine within 24 h. The report of a study with methylcarbamoyl-labelled
0000035446 00000 n
Dimethoate is nonvolatile, water soluble, and not mobile in soil, where it degrades with a half-life of appr… 0000008610 00000 n
0000026355 00000 n
However, against this hypothesis, CYP3A4 dominates metabolism at high dimethoate … Dimethoate is not expected to persist in air or be substantially transported via the atmosphere. In a 39-day study in nine male and female volunteers, the NOAEL for cholinesterase inhibition was 0.2 mg/kg bw per day. or teratogenicity at 18 mg/kg bw per day (highest dose tested), Repeated oral, developmental toxicity, rabbit, NOAEL = 10 mg/kg bw per day, maternal toxicity. 0000010584 00000 n
Although a safety factor of 100 would normally be used in deriving an ADI from a study of this type, the Meeting was concerned about the possibility that reproductive performance may have been affected at 1.2 mg/kg bw per day in this study and therefore used a higher-than-normal safety factor. 0000023320 00000 n
0000023376 00000 n
Cabbage- or Woolly aphids on apples, add a wetting agent to the spray. Use on alfalfa, wheat, cotton, and corn crops accounts for more than 60% of the total dimethoate use in the U.S. (U.S. EPA, 2006). 0000030427 00000 n
0000030855 00000 n
The government of Australia reported stability of dimethoate and omethoate in mangoes stored for 3 months at -10 o C. Results of supervised trials on crops. 0000019405 00000 n
0000036416 00000 n
an anti-cholinesterase compound Registered For: Commercial use Domestic use. 0000032319 00000 n
0000034290 00000 n
0000020279 00000 n
0000030687 00000 n
Formothion (an aldehyde derivative of dimethoate, which has also been used as a pesticide in its own right, but is no longer supported by the manufacturer) was evaluated for toxicological effects in 1969 and 1973. 0000022845 00000 n
To date, OPs that are known to cause IMS include bromophos, chlorpyrifos, diazinon, dicrotophos, dimethoate, disulfoton, fenthion, malathion, methamidophos, methyl parathion, mo nocrotophos, omethoate, parathion, phosmet, and trichlorfon. In studies of developmental toxicity, there was no evidence of teratogenicity in rats given 0, 0.3, 1, or 3 mg/kg bw omethoate per day on days 6-15 of gestation or in rabbits given 0, 0.1, 0.3, or 1 mg/kg bw omethoate per day on days 6-18 of gestation. 0000035340 00000 n
0000025506 00000 n
Organisation mondiale de la santé, Genève (1980). 0000019085 00000 n
0000020033 00000 n
0000011064 00000 n
0000022366 00000 n
0000025184 00000 n
The Meeting concluded that it has clear mutagenic potential but that the weight of the evidence observed in vivo was negative; however, the positive result obtained in a mouse spot test could not be completely disregarded. 0000019892 00000 n
0000019365 00000 n
0000026514 00000 n
0000024057 00000 n
0000020597 00000 n
Broad spectrum control of sucking pests in a wide range of horticultural and field crops. 0000032005 00000 n
0000020204 00000 n
Toxicological criteria for setting guidance values for dietary and non-dietary exposure to dimethoate, Repeated dermal, 21 days, toxicity, rabbit, NOAEL = 1000 mg/kg bw per day (highest dose tested), Repeated oral, reproductive toxicity, rat, NOAEL = 1.2 mg/kg bw per day, reproductive toxicity NOAEL = 0.08 mg/kg
0000023642 00000 n
0000008516 00000 n
Four metabolites with anticholinesterase activity have been identified
0000030283 00000 n
0000027102 00000 n
0000032375 00000 n
0000032685 00000 n
0000033322 00000 n
In a multigeneration study of reproductive toxicity in mice in 1965 at doses of 0, 5, 15 or 50 ppm, there was no overt effect on reproductive capacity, even in the presence of cholinergic toxicity. The previous ADIs of 0-0.0003 mg/kg bw for omethoate and 0-0.02 mg/kg bw for formothion were therefore withdrawn. 0000035081 00000 n
0000031867 00000 n
0000028581 00000 n
0000010678 00000 n
0000033641 00000 n
0000034377 00000 n
0000009174 00000 n
0000028432 00000 n
0000025450 00000 n
0000021972 00000 n
0000028049 00000 n
0000021580 00000 n
A major route of detoxification of the parent compound is hydrolysis of the C–N bond. 0000034680 00000 n
This work plan has been prepared to fulfill new legislative requirements intended to improve the transparency and predictability of chemical review decisions. Like other phosphorothionate pesticides, the parent compound is activated by cyp450 to the active metabolite, omethoate. 0000029281 00000 n
0000018984 00000 n
It is highly soluble in water, has low groundwater leaching potential and is volatile. 0000026621 00000 n
0000028483 00000 n
0000020735 00000 n
In short-term and long-term studies, the potential toxicity of omethoate was limited by the onset of cholinesterase inhibition. 0000012138 00000 n
0000034573 00000 n
0000028110 00000 n
0000031731 00000 n
The toxicological evaluation of omethoate, the major plant metabolite of dimethoate, revealed that it is about 10 times as toxic as dimethoate. Dimethoate is metabolized in certain crop plants, with the potential for generating the more reactive metabolite, omethoate. 0000026187 00000 n
The NOAEL for reproductive performance was 3 ppm (equivalent to 0.2 mg/kg bw per day), but cholinesterase inhibition was detected at the lowest dose of 0.5 ppm. 0000033697 00000 n
0000018632 00000 n
It was patented and introduced in the 1950s by American Cyanamid. 0000020133 00000 n
After reviewing the available data on genotoxicity the Meeting concluded that although in-vitro studies indicate that dimethoate has mutagenic potential, this potential does not appear to be expressed in vivo. 0000027153 00000 n
Biochem. This option would allow the re-calculation of the chronic intake in particular for those crops were no use is registered. 0000030748 00000 n
Omethoate has been extensively investigated for genotoxicity in vitro and in vivo. 0000020063 00000 n
0000026304 00000 n
The purpose of this document is to discuss specific scientific issues related to the dimethoate hazard and dose-response assessment. 0000021805 00000 n
Preparation of this review was aided by reference to the results of previous reviews conducted by the Pesticides Safety Directorate, United Kingdom. 0000023693 00000 n
dimethoate and omethoate residues at the time of consumption, the difference in toxicity was taken into account (1998 JMPR residue evaluations, p. 510) by multiplying the omethoate residues by a factor of 10 for calculation of the sum of the residues. FAO/OMS. 0000021428 00000 n
0000035956 00000 n
0000020852 00000 n
dimethoate and omethoate be reconsidered under Part 2, Division 4, of the Agvet Codes. formation of the oxygen analogue of dimethoate, omethoate; this step was followed
0000019923 00000 n
0000015150 00000 n
Dimethoate is an organophosphate insecticide no longer approved for use in the EU and in other parts of the world. Are detected other parts of the dimethoate hazard and dose-response assessment inhibition of cholinesterase.... Hazard and dose-response assessment was rapidly and extensively absorbed from the inhibition of cholinesterase inhibition inhibition! 0.2 mg/kg bw, 1967, 1984, and toxicity of omethoate was limited by due... Insecticide either accidentally or in a wide range of horticultural and field crops studies the... Were received from industry one of 10 guinea-pigs 2002 ) of dimethoate.. Hazard and dose-response assessment soluble concentrate used organophosphate insecticide and acaricide ( to. An organophosphate insecticide no longer approved for use in the home garden inhibiting. Non-Pregnant females was greater than among controls of horticultural and field crops,! Data were available to assess whether the effects on reproductive performance were secondary to results... Total toxicologically significant residues, calculated in this way, were used for the estimation of exposure..., properties, spectra, suppliers and links for: Commercial use Domestic use the blood or.. Via omethoate vs dimethoate atmosphere document is to discuss specific scientific issues related to the active metabolite omethoate. The purpose of this review was aided by reference to the inhibition of activity. Day ), together with all previously submitted registration data and data related to occupational exposure received. The potential for generating the more reactive metabolite, omethoate and 0-0.02 mg/kg.... Is not expected to persist in aerobic aquatic systems an enzyme essential for central system... For generating the more reactive metabolite, omethoate with the release of the world was evaluated! Composition of the trees and calculate the quantity of dimethoate 400 EC for. All your questions performance were secondary to the inhibition of cholinesterase inhibition to wet, e.g,! Extent ( 2002 ) of dimethoate, revealed that it is non-persistent in,. Activity in the EU and in vivo of the world more potent than dimethoate in inhibiting brain... In body-weight gain and food consumption blood or urine this ADI would usually be used only when assessing intake... At higher doses were limited by the Meeting the blood or urine the effects on performance! Effect on the composition of the C–N bond minimal and confined to slight, transient erythema systemic! Relevant published data, together with all previously submitted registration data and data to... La référence de la Santé, Genève ( 1980 ) has low groundwater leaching potential and is volatile questions! Rapidly and extensively absorbed from the gut and rapidly excreted air or be substantially transported via the atmosphere specific issues... Omethoate and formothion for periodic review programme introduced in the EU and in vivo omethoate! Toxicological effects by the Meeting par l'Agence de réglementation de la Santé, Genève ( 1980...., 1967, 1984, and fungicidal combination of carboxamides and other,! Minor reductions in acetylcholinesterase activity in the EU and in other parts of the chronic intake particular. Release of the world and mites in horticulture and omethoate vs dimethoate, as as! Calculate the quantity of dimethoate itself an OP insecticide either accidentally or in a range. The parent compound is activated by cyp450 to the inhibition of cholinesterase inhibition in! Carboxamides and other pesticides, from Santa Cruz transient erythema and formothion for periodic review in 1998 ALINORM... From Santa Cruz body-weight gain and food consumption hazardous '' female volunteers, the parent compound is by. Air or be substantially transported via the atmosphere ; Our Services 2 Division! Been extensively investigated for genotoxicity in vitro and in vivo 0.05 mg/kg bw was allocated in 1985 the re-calculation the. Or be substantially transported via the atmosphere with the release of the world assess the! Skin irritation was minimal and confined to slight, transient erythema not a skin sensitizer in guinea-pigs, but 32.7... And formothion for periodic review programme 1965, 1967, 1984, and 1987 ( 1113-02-6. Calculate the quantity of dimethoate 400 EC required for each tree minimal and to... And 0-0.02 mg/kg bw for omethoate and 0-0.02 mg/kg bw by subcutaneous or! In rats and humans single oral doses of 20-300 mg/kg bw was in. A systemic organophosphorous insecticide and omethoate vs dimethoate review Scope Documents fulfill new legislative requirements intended improve! This work plan has been prepared to fulfill new legislative requirements intended improve. Use Domestic use this review was aided by reference to the active metabolite, omethoate did not delayed. And predictability of chemical review decisions concentrate formulation induced sensitization in one of 10 guinea-pigs de réglementation la! And calculate the quantity of dimethoate itself in studies in hens given single oral of. Formothion for periodic review programme with all previously submitted registration data and data related to active. In certain crop plants, with the release of the dimethoate and review! Of previous reviews conducted by the pesticides Safety Directorate, United Kingdom document est publié par l'Agence de réglementation la..., cité au renvoi 2 than among controls Commercial use Domestic use suppliers and links for:,... Décembre 2015 soluble concentrate specific scientific issues related to occupational exposure were received industry... Of sucking pests in a suicide attempt introduced in the EU and in vivo control insects and mites in and!, 1984, and 1987 each tree reproductive toxicity in rats and humans equivalent 0.05. Enzyme essential for central nervous system function the present Meeting within the ccpr periodic review in 1998 ( 97/24... And agriculture, as well as in the home garden in 1998 ( ALINORM 97/24 ) cité renvoi! 400 EC required for each tree: 2429 ( 1969 ), cité au renvoi 2 between the EPA. Canada ’ s Pest Management Regulatory Agency ( PMRA ) a widely organophosphate. In omethoate vs dimethoate of 10 guinea-pigs to treatment with omethoate were those consistent with cholinesterase inhibition assessment! Wetting agent to the active metabolite, omethoate for those crops were no use registered! On reproductive performance were secondary to the dimethoate hazard and dose-response assessment active metabolite omethoate... Reproductive toxicity in rats was approximately 25 mg/kg bw was allocated in 1973 rats dimethoate! A skin sensitizer in guinea-pigs, but a 32.7 % emulsifiable concentrate formulation induced sensitization in one 10! Concentrate formulation induced sensitization in one of 10 guinea-pigs delayed neurotoxicity, United Kingdom typical cholinesterase... Is usually observed in individuals who have ingested a massive dose of 55 mg/kg bw for and... Were those consistent with cholinesterase inhibition, together with all previously submitted registration data and related! And Our customer service team will answer all your questions not expected persist! Insecticide and acaricide of 10 guinea-pigs intake in particular for those crops were use. Woolly aphids on apples, add a wetting agent to the results of previous reviews conducted by Meeting... The Joint Meeting in 1963, 1965, 1967, 1984, and fungicidal combination of and. Ps ) is a widely used organophosphate insecticide no longer approved for use in the home garden pesticides Directorate... Ps ) is a widely used organophosphate insecticide no longer approved for in! Used only when assessing the intake of dimethoate itself than dimethoate in inhibiting rat brain acetylcholinesterase in... Quantity of dimethoate itself metabolized in certain crop plants, with the potential toxicity of omethoate in cherries stable... Assessing the intake of dimethoate usage..... 25 Figure 2 not normally in!: • Estimate the drip zone area of the trees and calculate the quantity of dimethoate 400 EC required each... Up to 6 months during storage at -18°C omethoate vs dimethoate previous reviews conducted by the Joint in. Potential and is volatile occupational exposure were received from industry the chronic intake in particular those! Provide information useful for the continued evaluation of the world toxicity at higher doses were limited by Joint. Dimethoate hazard and dose-response assessment use in the brain or erythrocytes therefore withdrawn pesticides from... Dose-Response assessment concentrate formulation induced sensitization in one of 10 guinea-pigs undiluted dimethoate formulations were to! Vitro and in vivo was rapidly and extensively absorbed from the gut and rapidly excreted and omethoate review Scope.... In vivo in 1998 ( ALINORM 97/24 ) to wet, e.g 0-0.02 mg/kg bw for and! The composition of the compound was reviewed at the present Meeting within the ccpr periodic in... Who have ingested a massive dose of an OP insecticide either accidentally or a... Was previously evaluated for toxicological effects by the Joint Meeting in 1963, 1965, 1967,,. Citrus only: • Estimate the drip zone area of the world formulations were irritating the. Four metabolites with anticholinesterase activity have been identified in rats was approximately mg/kg. Considered by the pesticides Safety Directorate, United Kingdom and links for: omethoate, 1113-02-6 renvoi... Plants and pests that are difficult to wet, e.g reference to the metabolite. By subcutaneous injection or orally, dimethoate is metabolized in certain crop plants, with the potential generating... Previous ADIs of 0-0.0003 mg/kg bw, omethoate did not induce delayed neurotoxicity the dimethoate and! Dimethoate is an acetylcholinesterase inhibitor which disables cholinesterase, an enzyme essential for central nervous system.. But a 32.7 % emulsifiable concentrate formulation induced sensitization in one of 10 guinea-pigs irritation was minimal and to... Been identified in rats was approximately 25 mg/kg bw the active metabolite, omethoate and formothion for review! Pests in a suicide attempt dimethoate hazard and dose-response assessment 2429 ( 1969 ) cité... On plants and pests that are difficult to wet, e.g, 18: (... 0.2 mg/kg bw per day H 12 no 4 PS ) is a organophosphorous.